Founded by Viceroy Faykan Butler, the grandson of Xavier Harkonnen and grandnephew of Serena Butler. Faykan had married Jessica Boro-Ginjo, a descendant of both the first Grand Patriarch Iblis Ginjo and also of the last Emperors of the Old Empire. In a speech given immediately after the Battle of Corrin, the final battle of the Butlerian Jihad, Faykan takes much of the credit for the victory (though the battle was mainly organized and carried out by Supreme Bashar Vorian Atreides) and announces that he intends to change his name to Corrino in recognition of this historic event. He then combines the positions of Viceroy and Grand Patriarch into one office, declaring himself Emperor of Humanity.
Members of this Imperial House ruled as Padishah Emperors of the Known Universe for over 10,000 years, from the time of the Butlerian Jihad until the defeat of the 81st Padishah Emperor Shaddam Corrino IV by "Muad'Dib" (Paul Atreides) and the Fremen. Shaddam IV has five daughters, though only two play a part in the events of the Dune saga; the Bene Gesserit-trained Princess Irulan marries Paul in a political alliance designed to effect his accession to the throne and her sister Princess Wensicia later plots to place her son Farad'n on the throne.
The Imperial House Corrino's ancestral planet is Salusa Secundus, the original seat of imperial power since the Butlerian Jihad, but the Royal Court is at some point moved to the planet Kaitain before the events of Dune. The harsh conditions on Salusa Secundus allow the Corrinos to develop the universe's most-feared military unit, the warrior-fanatic Sardaukar, the means by which House Corrino controls the Empire.
Padishah Elrood Corrino IX was murdered by Count Hasimir Fenring at his sons Shaddam's request in 10 156 A.G. Shaddam Corrino then ise to power. Shaddam was also complicit in the murder of his own elder brother, the Crown Prince Fafnir, and had secretly administered contraceptives to his own mother, Habla, so she couldn't conceive another son to rival him.
Salusa Secundus was devastated by atomics by a renegade House which is subsequently exterminated, their name erased from history. The planet was intentionally left as a barren wasteland until the defeat of the 81st Padishah Emperor Shaddam Corrino V by Paul Atreides and the Fremen of Dune.
Following their exile to Salusa Secundus by Paul Atreides the Corrinos gradually recover strength. A bitter Irulan—frustrated by Paul's love for his concubine Chani and his refusal to let her be the mother of his heirs—conspires against Paul with representatives of both the Bene Gesserit and Bene Tleilax. After the deaths of both Paul and Chani, a remorseful Irulan defects from the Bene Gesserit and dedicates herself to raising their infant children, twins Leto and Ghanima.
Years later Wensicia sets in motion a plan to assassinate the twins and place her son Farad'n, the grandson of Shaddam IV and the last hope for a new Corrino Emperor, on the throne. The plot ultimately fails, and Paul's heirs Leto and Ghanima rise to power at the death of the Regent, Paul's sister Alia. Leto is rendered sterile by the process of becoming a human-sandworm hybrid so, to continue the line, he reaches an agreement with Farad'n: Leto will marry Ghanima in a political arrangement, but Farad'n (who will never rule or marry Ghanima) will father all future heirs apparent to the throne.
Following Leto II's death after 3,500 years of rule, Siona Atreides, a descendant of Farad'n and Ghanima and the culmination of Leto's own breeding program, assumes stewardship of his empire with Duncan Idaho.
However, the Empire of a Million Worlds ultimately collapses in The Scattering, as billions flee chaos and famine to seek new opportunities in unknown space. Some 1,500 years later, Duncan and Siona's powerful bloodline permeates the universe and lives on in such luminaries as Miles Teg and Darwi Odrade.